Gene expression analysis and metabolic optimization in cortical fast-spiking interneurons
نویسندگان
چکیده
منابع مشابه
Cortical Pyramidal Cells and Fast-spiking Interneurons
21 Tonically-activated neuronal currents mediated by N-methyl-D-aspartate receptors (NMDARs) 22 have been hypothesized to contribute to normal neuronal function as well as to neuronal 23 pathology resulting from excessive activation of glutamate receptors (e.g., excitotoxicity). While 24 cortical excitatory cells are very vulnerable to excitotoxic insult, the data regarding resistance of 25 inh...
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Cortical fast-spiking (FS) interneurons display highly variable electrophysiological properties. Their spike responses to step currents occur almost immediately following the step onset or after a substantial delay, during which subthreshold oscillations are frequently observed. Their firing patterns include high-frequency tonic firing and rhythmic or irregular bursting (stuttering). What is th...
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A physiological brain function requires neuronal networks to operate within a well-defined range of activity. Indeed, alterations in neuronal excitability have been associated with several pathological conditions, ranging from epilepsy to neuropsychiatric disorders. Changes in inhibitory transmission are known to play a key role in the development of hyperexcitability. However it is largely unk...
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Fast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic interactions control synchronization, artificial synaptic conductances were injected in FS cells...
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Tonic conductance mediated by extrasynaptic GABAA receptors has been implicated in the modulation of network oscillatory activity. Using an in vitro brain slice to produce oscillatory activity and a kinetic model of GABAA receptor dynamics, we show that changes in tonic inhibitory input to fast spiking interneurons underlie benzodiazepine-site mediated modulation of neuronal network synchrony i...
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ژورنال
عنوان ژورنال: Frontiers in Systems Neuroscience
سال: 2009
ISSN: 1662-5137
DOI: 10.3389/conf.neuro.06.2009.03.175